However, there is a lack of information concerning the evidence-based clinical annotations of specific CYP2E1 genetic variants.Īim: To design and evaluate the next-generation sequencing-based method for full-length CYP2E1 gene polymorphism analysis. Introduction: Pharmacogenetics studies provide clinically relevant information on the identified associations between genetic variants and individual variability in drug response, which, in turn, offers great promise for guiding personalized drug therapy and clinical trial design. Viktorija Igumnova, 1, 2 Agnija Kivrane, 1, 2 Anda Viksna, 3, 4 Inga Norvaisa, 4 Renate Ranka 1, 2ġMolecular Microbiology Group, Latvian Biomedical Research and Study Centre, Riga, Latvia 2Department of Pharmaceutical Chemistry, Riga Stradins University, Riga, Latvia 3Department of Infectology, Riga Stradins University, Riga, Latvia 4Centre of Tuberculosis and Lung Diseases, Riga East University Hospital, Riga, LatviaĬorrespondence: Renate Ranka, Molecular Microbiology Group, Latvian Biomedical Research and Study Centre, Ratsupites Street 1, k-1, Riga, Latvia, Tel +371 67808218, Email
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